Hypertension as a result of an increase in arachidonic acid (AA) ω-hydroxylase (20-HETE synthesis) activity of cytochrome P450s CYP4A, CYP4F, and CYP1B1 is well established. Thus, 20-HETE has become a biomarker and therapeutic target for hypertension and stroke. This ELISA kit is suitable for measuring 20-HETE in up to 24 biological samples in-triplicate.
New References Using Our 20-HETE ELISA
1 .Bou-Fakhredin, R. et al. (2021) CYP450 mediates reactive oxygen species production in a mouse modl of B-thalassemia through an increase in 20-HETE activity. Int. J. Mol. Sci 22:110. PMID: 33498614 CYP4A and CYP4F-induced 20-HETE production mediates reactive oxygen species overgeneration in Hbbth3/+ mice.
2. Yu, J. et al. (2021) Cytochrome P450 CYP2E1 suppression ameliorates cerebal ischemia reperfusion injury. Antioxidants 10, 52. PMID: 33466250 20-HETE production increased 41% in CYP2E1 KO mice following ischemia reperfusion injury.
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